Neuron is fundamental unit of AI neural networks, ranging from Machinery; AGV/AMR; EHS Devices to On-site Personnel, we consider each entity as an AI human-machine network neuron of the Smart Factory. Through CT heterogeneous network switching which connects all production machinery; moving; safety and portable devices then extracts valuable information and combines it with extensive manufacturing data. Ultimately, AI system optimizes OT applications for maximizing OEE; ESG and presents TCO and ROI immersive management Digital Twins solution for delivering Manufacturing Intelligence.